Study of CD73 Expression on B Lymphocytes in patients with chronic lymphocytic leukemia

Background: A subgroup of T and B cells express the extracellular enzyme cluster differentiation (CD73), which hydrolyzes adenosine monophosphate to adenosine. This work aimed evaluate CD73 expression its correlation with other disease characteristics in leukemia chronic lymphocytic type (CLL) patients. Methods: cross-sectional research was done on 30 CLL cases diagnosed by laboratory investigations or presented fatigue fever without lymphadenopathy organomegaly, a healthy control group age- sex-matched individuals. All patients had subjected estimation β2 microglobulin, flowcytometric detection CD19 peripheral blood. Results: In neither did CD19/CD73 haemoglobin significantly correlate. microglobulin group. While, positive significant B2 macroglobulin group, level, platelet count, were all noticeably reduced. however, greater can diagnose high accuracy (100%) at cut-off 16.8, sensitivity, specificity, PPV NPV 100%. Conclusions: When compared controls, most have less CD19CD73, making it useful standard diagnostic immunophenotyping workup. At point has sensitivity for diagnosis CLL.